Recombinant adeno-associated virus as vaccine delivery vehicles
نویسندگان
چکیده
Komal Vig, Roland Herzog, Douglas Martin, Eddie G. Moore, Vida A. Dennis, Shreekumar Pillai, Shree R. Singh* Center for NanoBiotechnology Research, Alabama State University, Montgomery, AL 36101, USA Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA Scott-Ritchey Research Center, Auburn University, Auburn, AL 36832, USA Department of Biological Sciences, Alabama State University, Montgomery, AL 36101, USA __________________________________________________________________________________
منابع مشابه
Protection against infectious bursal disease virulent challenge conferred by a recombinant avian adeno-associated virus vaccine.
The development and use of recombinant vaccine vectors for the expression of poultry pathogens proteins is an active research field. The adeno-associated virus (AAV) is a replication-defective virus member of the family Parvoviridae that has been successfully used for gene delivery in humans and other species. In this experiment, an avian adeno-associated virus (AAAV) expressing the infectious ...
متن کاملRecombinant adeno-associated virus derived vectors (rAAV2) efficiently transduce ovarian and hepatocellular carcinoma cells--implications for cancer gene therapy.
Recombinant adeno-associated virus vectors (rAAV) represent a most promising gene delivery vehicles for gene therapy applications because their unique properties, such as capability to infect both proliferating and non proliferating cells of broad host range, and possibilities of long-term expression and site-specific integration. rAAV are also described as vectors neither toxic nor pathogenic ...
متن کاملConstruction and Detection of Recombinant Adeno-Associated Virus Co- Expressing PRRSV GP5, M Proteins and shRNA
Porcine reproductive and respiratory syndrome virus (PRRSV) is a severe threat to the swine industry and has caused heavy economic losses worldwide. The currently used inactivated and attenuated virus vaccines have several shortcomings, such as unsafety and low protection rate, so it is urgent to develop a new vaccine. To explore and develop a novel vaccine against PRRSV, a bi-functional recomb...
متن کاملطراحی و ساخت نانو زیست ذرات فاژی نوترکیب به عنوان کاندیدای حامل واکسن ژنی- خوراکی
Background and Objective : Bacteriophage vectors recently have been considered as a gene transfer and vaccine delivery vehicles chiefly due to their low cost, safety, and physical stability. Since, little is known about phage mediated gene transfer in mammalian hosts, A group of invitro experiments were performed to ascertain gene transfercapability of these vehicles . Materials and Methods...
متن کاملRecombinant adeno-associated virus encoding Epstein-Barr virus latent membrane proteins fused with heat shock protein as a potential vaccine for nasopharyngeal carcinoma.
Nasopharyngeal carcinoma (NPC) is a common cancer in Southern China and EBV is the most important pathogenesis. In this study, we explore the potential that a recombinant adeno-associated virus (rAAV) carrying a fusing gene containing heat shock protein as an adjuvant, EBV latent membrane proteins (LMP1 and LMP2) CTL epitope DNA as a vaccine prevents NPC. The tumor vaccine was devised by constr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2008